eLife

Separating selection from mutation in antibody language models

This important study introduces a new biology-informed strategy for deep learning models aiming to predict mutational effects in antibody sequences. It provides solid evidence that separating ...
Nature

Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin α

Importin α is the nuclear import receptor that recognizes classical monopartite and bipartite nuclear localization signals (NLSs). The structure of mouse importin α has been determined at 2.5 Š...