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The San Francisco 49ers defeated the Indianapolis Colts 48-27 on Monday night, in their fifth straight win. Purdy threw for 295 yards, finishing with a career-high five touchdowns. Christian McCaffrey rushed 21 times for 117 yards, making six catches for 29 yards and two touchdowns.

The Rams are running it back with the same uniform set that they wore in their playoff win over the Panthers last week.