A sum of 921 samples were collected from three independent data sets. We obtained pyroptosis-related genes from both the Molecular Signatures Database and relevant literature sources and used four ...

At the onset of diabetic cardiomyopathy, Trdn-as expression increases, which regulates the methylation of Casq2 mRNA mediated by METTL14, thus increasing the stability and expression of Casq2 mRNA.

A study in mouse models and human tissue, carried out by researchers at the Barcelona Institute of Science and Technology Centre for Genomic Regulation (CRG), has found that the small nuceleolar RNA ...

When a gene produces too much protein, it can have devastating consequences on brain development and function. Patients with an overproduction of protein from the chromodomain helicase DNA binding ...

Smaller noncoding RNA is being used in clinical practice and as knowledge grows of long noncoding RNA, use of it should follow, explained Laura Denby, PhD, Kidney Research UK Senior Fellow, senior ...

Various sayings equate going fast with going alone. But none of them apply to the gene expression journey described by a research team from the University of Göttingen. The team, led by Heike Krebber, ...

Crystal structure of the NHL domain of mouse TRIM71 complexed with a stem-loop structured Trincr1 RNA motif. Detailed interactions between key residues of TRIM71 and Trincr1 RNA are shown in an ...

TRIM71, also known as Lin-41, belongs to the TRIM-NHL RNA-binding ubiquitin ligase protein family. It was first discovered as a heterochronic gene regulated by microRNA (miRNA) let-7 during C. elegans ...